DESIGN, SYNTHESIS AND ANTITUMOR EVALUATION OF NOVEL PYRAZOLO[3,4-D]PYRIMIDINES INCORPORATING DIFFERENT AMINO ACID CONJUGATES AS POTENTIAL DHFR INHIBITORS

The present study aimed to investigate the antitumor effect of simultaneous inhibition of dihydrofolate reductase (DHFR) enzyme.We designed some novel pyrazolo[3,4-d]pyrimidines bearing different amino acid conjugates as efficient antifolate agents attributable to their structural similarity with methotrexate (MTX) and MTX-related antifolates.All c

Accurate evaporation duct prediction is one of the critical technologies for realizing the over-the-horizon impact of marine communication, ship radar, and other systems.Using GPS signals to invert evaporation ducts provides more benefits in 6-Piece Power Reclining Sectional terms of method realization and ease.In order to invert the evaporation du

Rashid Menhas,1 Jianhui Dai,2 Muhammad Azeem Ashraf,3 Sohail M Noman,4 Sumaira Khurshid,5 Sajid Mahmood,6 Yu Weng,2 Rizwan Ahmad Laar,7 Xuehui Sang,2 Muhammad Kamran,8 Babar Shahzad,9 Waseem Iqbal9 1Research Center of Sports Social Sciences, School of Physical Education and Sports, Soochow University, Suzhou, 215006, Jiangsu Province, People’

To what extent, if any, should the law protect sentient artificial intelligence (that is, AI that can feel pleasure or pain)? Here we surveyed United 5 Piece Modular Sectional States adults (n = 1,061) on their views regarding granting 1) general legal protection, 2) legal personhood, and 3) standing to bring forth a lawsuit, with respect to sentie